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Dermoscopy Insights Into Nevogenesis"Abtropfung" vs "Hochsteigerung"
Iris Zalaudek, MD;
Gerardo Ferrara, MD;
Giuseppe Argenziano, MD
Department of Dermatology, Medical University of Graz, Graz, Austria (Dr Zalaudek); Pathologic Anatomy Service, Gaetano Rummo General Hospital, Benevento, Italy (Dr Ferrara); Department of Dermatology, Second University of Naples, Naples, Italy (Dr Argenziano)
Arch Dermatol. 2007;143(2):284.
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Two concepts, the "Abtropfung" and the "Hochsteigerung," have been used to explain the natural evolution of melanocytic nevi. The nevi in Figure 1 and Figure 2 are located on the respective backs of a 25- and a 20-year-old woman. By dermoscopy, the former first exhibited a central bluish pigmentation indicating pigmented cells in the papillary dermis (Figure 1A), while a significant color change toward brown occurred after 8 months (Figure 1B), reflecting the presence of pigment at the dermoepidermal junction. The nevus in Figure 2 reveals an opposite trend after 1 year of follow-up, with significant change of the color from brown (Figure 2A) to blue (Figure 2B). Whether this is caused by a real movement of cells (upward or downward) or by a different activation and/or maturation level of melanin-producing melanocytes remains . . . [Full Text of this Article]
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