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  Vol. 143 No. 3, March 2007 TABLE OF CONTENTS
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  The Cutting Edge: Challenges in Medical and Surgical Therapeutics
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 •Dermatologic Disorders, Other
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Adalimumab Treatment for Pyoderma Gangrenosum

Michael P. Heffernan, MD; Milan J. Anadkat, MD; David I. Smith, MD

Arch Dermatol. 2007;143(3):306-308.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

REPORT OF A CASE

A 47-year-old woman was referred to Washington University dermatology clinic for a nonhealing ulcer on her right shin of 8 months' duration. She reported having had a similar ulcer on her left shin 6 years ago. The patient's medical history was significant for non–insulin-dependent diabetes mellitus, hypertension, and osteoarthritis. On examination, she was found to have a x 3-cm punched-out ulcer with rolled borders on her right shin. Evaluation of a biopsy specimen taken 6 months prior to presentation showed extensive dermal necrosis with ulceration and abscess formation and microangiopathy manifested by thickening of the capillary walls with fibrinous deposits and microthrombi. The overall histologic findings were thought to be most consistent with atrophie blanche.

Further evaluations at presentation included a complete blood cell count with differential and rheumatoid factor, both of which were within normal limits. . . . [Full Text of this Article]

CLINICAL CHALLENGE

SOLUTION

COMMENT

AUTHOR INFORMATION

Divisions of Dermatology, Wright State University School of Medicine, Dayton, Ohio (Dr Heffernan) and Washington University School of Medicine, St Louis, Mo (Drs Anadkat and Smith)







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