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Arch Dermatol. 2007;143(3):417-422.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Cutaneous diffuse large B-cell lymphoma.

MICROSCOPIC FINDINGS, LABORATORY FINDINGS, AND CLINICAL COURSE

Biopsy specimens revealed a primary cutaneous diffuse large B-cell lymphoma. A dense monomorphous infiltrate of mononuclear cells extended from the upper reticular to the deep dermis. Scattered among the mononuclear cells were larger atypical CD20⁺ B cells with hyperchromatic nuclei. Immunoperoxidase stains showed a smaller amount of reactive CD45RO⁺, CD3⁺, CD5⁺, and CD79a^– T cells. Stains were negative for CD30, CD43, and and immunoglobulin light chains and strongly positive for Bcl-2. Gene rearrangement studies were positive for a monoclonal B-cell population, and polymerase chain reaction analysis revealed an IgG heavy-chain rearrangement. The extent of involvement of the ears made radiation therapy and local excision impractical. Also, considering the expected good prognosis, intensive chemotherapy was inappropriate. The patient was treated with rituximab, a chimeric monoclonal anti-CD20 antibody, at a dosage of 375 mg/m² per day for 4 consecutive weeks, resulting in complete resolution of her disease.

DISCUSSION

Primary cutaneous . . . [Full Text of this Article]