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Arch Dermatol. 2007;143(4):535-540.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Fixed drug eruption (FDE).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the biopsy specimen showed vacuolar degeneration of basal cells and necrotic keratinocytes sandwiched between orthokeratotic stratum corneum and regenerating epithelium of the lower epidermis. In the dermis, edema and extravasated erythrocytes as well as a superficial and deep mixed inflammatory infiltrate with some eosinophils were observed (Figure 2).

Figure appears in full text version. Figure 2.

The patient's lesions rapidly improved on treatment with a medium-potency topical corticosteroid. Two months later, patch testing with 10% co-trimoxazole in either petrolatum or aqueous base applied to the left pretibial area and to the back was performed and yielded negative results. Subsequently, trimethoprim and sulfamethoxazole were dissolved in dimethylsulfoxide at concentrations of 10% and 20% wt/vol and applied twice daily for 3 days to both left and right pretibial areas and to the back as described by Özkaya-Bayazit et al.¹ Within 72 hours, the patient developed a bullous test reaction to 20% trimethoprim on . . . [Full Text of this Article]

DISCUSSION