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Arch Dermatol. 2007;143(4):535-540.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Nodular localized primary cutaneous amyloidosis.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Hematoxylin-eosin–stained sections of the specimen demonstrated an atrophic epidermis. Nodular deposits of amorphous eosinophilic material were found in the middle and deep dermis. There were prominent clefts within this material and a lymphoplasmacytic infiltrate surrounding it. A Congo red stain confirmed the presence of amyloid. The material also demonstrated apple-green birefringence on polariscopic examination. The results of systemic workup, including serum and urine protein electrophoresis, have been negative to date. Our patient is currently scheduled for carbon dioxide laser treatment of his lesions.

DISCUSSION

There are 3 types of primary cutaneous amyloidosis: macular, papular (lichenoid), and nodular (tumefactive). Nodular amyloidosis, also known as amyloidosis cutis nodularis atrophicans, is the rarest of the 3 types. Typically, patients with nodular amyloidosis present in middle age, with men and women equally affected. Cutaneous lesions are described as single or multiple waxy papules, nodules, or plaques commonly located on the limbs, face, trunk, or . . . [Full Text of this Article]

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