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Arch Dermatol. 2007;143(5):653-658.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Atypical fibroxanthoma (AFX).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the specimen showed a highly cellular ulcerated tumor limited to the dermis. There was a dense, chaotic arrangement of atypical plump spindle-shaped cells, pleomorphic round or polyhedral cells with abundant eosinophilic cytoplasm, and mononucleated or multinucleated giant cells, often with bizarre nuclei. Mitoses were numerous and sometimes abnormal. The stroma was scarce, with a discrete inflammatory infiltrate. The tumor was limited to the superficial and middle dermis and contiguous to an unaffected epidermis. There was no vascular or lymphatic invasion. Immunohistochemical stains were positive for CD68 and negative for HMB-45, melan-A, S100 protein, CD31, CD34, and cytokeratin. The diagnosis of AFX was made. Treatment consisted of surgical excision, with a margin of 15 mm because of the unusually large size of the tumor, followed by skin graft.

DISCUSSION

Atypical fibroxanthoma, also termed pseudosarcoma, paradoxical fibrosarcoma, and pseudosarcomatous reticulohistiocytoma, was first described by Helwig¹ in 1961. . . . [Full Text of this Article]