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Therapeutic Breakthroughs Remain Elusive

Matthew H. Kanzler, MD

Arch Dermatol. 2007;143(6):785-787.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this month's ARCHIVES, González¹ and Tsai² provide evidence-based critiques of 2 recently published articles regarding cutaneous melanoma. These articles evaluate the clinical utility of sentinel node biopsies (SNBs) and systemic therapy for patients with high-risk melanoma. Both topics have generated much discourse over the past decade, as until recently, "standards of care" have been dictated by theories and consensus owing to the lack of good evidence.

González¹ provides an excellent commentary on the results of the Multicenter Selective Lymphadenectomy Trial (MSLT-I),³ which evaluated the effectiveness of SNB in patients with cutaneous melanoma. The MSLT-I is an excellent example of a "negative" study given a positive "spin" by the authors. In fact, the negative results of the primary aim of this study are nowhere to be found in the conclusions of the article's abstract.

While the MSLT-I was generally well designed and executed, inappropriate use . . . [Full Text of this Article]

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