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Arch Dermatol. 2007;143(6):791-796.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Calciphylaxis (calcific uremic arteriolopathy) associated with chronic renal failure.

MICROSCOPIC, LABORATORY, AND RADIOLOGIC FINDINGS AND CLINICAL COURSE

The biopsy specimen demonstrated hemorrhagic infarction of the entire dermis and epidermis. The underlying fatty subcutis showed extensive calcification but no obvious vasculitis or panniculitis (Figure 2). There was also calcification present in association with a venule (Figure 3). A review of blood test results from the preceding 2 years showed high parathyroid hormone levels peaking to 199 mg/dL (21 pmol/L) (RR, 15-66 mg/dL [1.6-6.9 pmol/L]), with an elevated calcium-phosphate product. A radiograph of the lower leg showed extensive vascular calcification, which is common in the lower extremities of patients with end-stage renal failure, however, and is not specific for calciphylaxis. The diagnosis of calciphylaxis was made.

Figure appears in full text version. Figure 2.

Figure appears in full text version. Figure 3.

The patient required opioid analgesia to control the pain. Nonadherent, silicone-based dressings were applied to the ulcer. Recurrent soft tissue infections in the surrounding skin were treated aggressively with antibiotics, and the dosage of aluminum . . . [Full Text of this Article]

DISCUSSION

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Arch Dermatol. 2007;143(6):791-796.
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