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Arch Dermatol. 2007;143(6):791-796.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Acral persistent papular mucinosis (APPM).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Hematotoxylin-eosin–stained sections showed a normal epidermis with an accumulation of a substance within the papillary and reticular dermis. This substance stained positive for mucin with alcian blue (pH, 2.5) and periodic acid–Schiff. There was increased spacing between collagen bundles but no increase in fibroblast numbers. There was no subepidermal grenz zone.

The results of laboratory investigations, including a complete blood cell count, erythrocyte sedimentation rate, biochemical profile, thyroid function tests, autoantibody profile, serum protein electrophoresis and immunoelectrophoresis, and fasting cholesterol levels, were all within normal range. Treatment was initiated with a course of incision followed by topical liquid nitrogen, with good response to date.

DISCUSSION

Rongioletti et al¹ were the first to identify APPM as a distinct entity in 1986 and later described it as a subtype of localized lichen myxedematosus (LM) in a comprehensive review in 2001.² They distinguished 3 clinicopathologic types of LM: a generalized form with systemic manifestations . . . [Full Text of this Article]

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Arch Dermatol. 2007;143(6):791-796.
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