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Paolo Carli, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Kittler et al¹ found that after 4.5 months, 61.8% of melanomas did not show specific features of malignancy, and after 8.0 months, 35.1% of melanomas were not classifiable as melanoma without sequential dermoscopic examination. Therefore, the authors concluded that observations of change in the lesions can help the physician detect melanoma when there are no other visible signs of malignancy.

The first point of concern is the reliability of the histopathologic diagnosis. A panel of 9 histopathologists examining reproducibility found that 35.6% of equivocal melanocytic lesions with at least 1 dissenting dermoscopic diagnosis received at least 1 dissenting histopathologic diagnosis.² There is quite good correlation between dermoscopic and histopathologic features. What is the reliability of the pathologic diagnosis for a lesion that is neither clinically nor dermoscopically a melanoma? Studies on reproducibility of this diagnosis are needed.

The second point of concern is the cost-effectiveness of this . . . [Full Text of this Article]

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