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Arch Dermatol. 2007;143(7):937-942.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Epithelioid hemangioendothelioma (EHE).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

A punch biopsy specimen of the skin from the left knee showed a dermal neoplasm composed of epithelioid and spindle cells with nuclei containing clumped chromatin and prominent nucleoli set in a homogeneous eosinophilic and basophilic stroma. In some areas, the cells had intracytoplasmic vesicles and/or intracytoplasmic erythrocytes. No necrosis or mitotic activity was identified. The neoplasm was positive for vimentin, CD31, and CD34 and negative for cytokeratin and S100 protein. The histologic findings and the immunophenotype were consistent with an EHE.

Our patient was referred to surgery for wide excision of the neoplasm. The surgeon noted a small, tender lymph node in her left groin that had not been detected by positron emission tomography. Histologic analysis of the primary tumor again revealed no involvement of the subcutis. The palpable lymph node persisted and a biopsy was performed. Metastatic EHE was identified in 2 of 2 lymph nodes. A radical . . . [Full Text of this Article]

DISCUSSION

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Arch Dermatol. 2007;143(7):937-942.
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