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A Possible Therapeutic Target?

Pedro Redondo, MD, PhD; Antonio Martínez-Cuesta, MD; Emilio G. Quetglas, MD; Michel Idoate, MD, PhD

Arch Dermatol. 2007;143(8):1043-1045.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Vascular malformations result from the aberrant development of vascular elements during embryogenesis and fetal maturation. Despite apparent endothelial quiescence, some vascular malformations can expand rapidly during adolescence or pregnancy, after a surgical procedure, or in response to trauma. The pathogenesis of vascular malformations is not well clarified, but their formation and progression are closely related to angiogenesis, a complicated network that is closely regulated by many angiogenic factors.¹

REPORT OF A CASE

A 51-year-old man presented with an arteriovenous malformation in the left side of the trunk and arm (Figure, A). At the age of 20 years he underwent an amputation of his left arm because of incoercible repeated hemorrhagic episodes. Since then, the lesion has progressively grown, and soft, large, circumscribed blue-black tumors that repeatedly bleed have appeared.

Figure appears in full text version. Figure. Extensive arteriovenous vascular malformation in the . . . [Full Text of this Article]

COMMENT

AUTHOR INFORMATION

Author Affiliations: Departments of Dermatology (Dr Redondo), Radiology (Dr Martínez-Cuesta), Pharmacology (Dr Quetglas), and Pathology (Dr Idoate), University Clinic of Navarra, School of Medicine, Pamplona, Spain.