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Frequency of Shifts Over Time in the Profile of Antidesmoglein Antibodies in Pemphigus Vulgaris
Daniel Weitz, MD;
Jean-Claude Bystryn, MD
Arch Dermatol. 2007;143(8):1073-1074.
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The clinical features of pemphigus vulgaris (PV) are related to the presence and profile of antidesmoglein 3 (anti-dsg3) and antidesmoglein 1 (anti-dsg1) antibodies.1 Anti-dsg3 is associated with mucosal PV; the concurrent presence of anti-dsg3 and anti-dsg1, with mucocutaneous disease; and anti-dsg1 alone, with pemphigus foliaceus (PF). Shifts over time in the pattern of anti-dsg antibodies from that associated with PV to that seen in PF have been described in several case reports.2-10 How often these serologic shifts occur is unknown. The present study was conducted to examine the frequency and the types of shifts in the profile of anti-dsg3 and anti-dsg1 that occur in patients with PV.
Methods
Thirty-seven sequential patients with PV who satisfied the following criteria were studied: (1) PV diagnosis based on clinical, histologic, and immunologic criteria; (2) intercellular antibodies at baseline assayed by indirect immunofluorescence; (3) at least 2 serum specimens . . . [Full Text of this Article]
Results
Comment
AUTHOR INFORMATION
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