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Arch Dermatol. 2007;143(9):1201-1206.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Cutaneous papillomas associated with Costello syndrome.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the left arm lesion showed a hyperplastic epidermis with vascular ectasia and a mononuclear cell infiltrate in the dermis. The findings were consistent with verrucous acanthoma (papilloma). The patient was referred to the plastic surgery department to discuss treatment options for the facial papillomas.

DISCUSSION

Approximately 150 cases of Costello syndrome have been identified since the condition was described in 1977 by Costello¹ and later named by Der Kaloustian et al² in 1991. The major features include growth and mental retardation, with a sociable personality; coarse facies (macrocephaly, thick lips, big tongue, depressed nasal bridge, and low-set ears with thick lobes); short neck; musculoskeletal abnormalities (tight Achilles tendon, hyperextensible fingers, and limited joint mobility), cardiac defects (hypertrophic cardiomyopathy, cardiac malformations, and supraventricular arrhythmias); increased risk for malignant tumors (rhabdomyosarcoma, ganglioneuroblastoma, neuroblastoma, and bladder carcinoma); and distinctive cutaneous findings.³ Cutaneous papillomas are a unique skin manifestation of Costello syndrome, . . . [Full Text of this Article]

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Arch Dermatol. 2007;143(9):1201-1206.
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