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COMMENTS AND OPINIONS
Allergic Contact Dermatitis: Another Adverse Effect of Over-the-counter Topical Hydrocortisone
Kalman L. Watsky, MD;
Erin M. Warshaw, MD, MS
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We read with interest the commentary in the March 2007 issue of the Archives of Dermatology titled "Topical Hydrocortisone From Prescription to Over-the-Counter Sale."1 While this article aptly describes the historical debate regarding approval for over-the-counter drug (OTC) use, it neglects to include allergic contact dermatitis from corticosteroids as 1 of the adverse effects of topical hydrocortisone.2-9
Corticosteroid allergy was first described in 1959 by Burckhardt10 but has become more widely recognized since the introduction of tixocortol-21-pivalate as a patch-test marker in the late 1980s. Prevalence of allergy to tixocortol, a marker for allergy to hydrocortisone and other group A corticosteroids, has ranged from 2.3% to 2.9% in large patch-tested populations in North America. Clinical relevance to the presenting dermatitis is documented in more than 80% of cases.
The ready availability of OTC hydrocortisone products likely contributes to this high prevalence . . . [Full Text of this Article]
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RELATED LETTER
Allergic Contact Dermatitis: Another Adverse Effect of Over-the-counter Topical Hydrocortisone—Reply
William H. Eaglstein and Scott M. Ravis
Arch Dermatol. 2007;143(9):1217-1218.
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RELATED ARTICLE
Topical Hydrocortisone From Prescription to Over-the-Counter Sale: A Past Controversy: A Cautionary Tale
Scott Michael Ravis and William H. Eaglstein
Arch Dermatol. 2007;143(3):413-415.
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