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Arch Dermatol. 2008;144(1):105-110.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Epithelioid cell histiocytoma (ECH).

MICROSCOPIC FINDINGS

Hematoxylin-eosin–stained sections showed a relatively well-circumscribed dermal proliferation of epithelioid cells with eosinophilic, slightly "foamy" cytoplasm. Isolated mitotic figures were observed. An extensive panel of immunostains revealed no significant staining with CD31, actin, epithelial membrane antigen, pancytokeratin, HMB-45, or Mart-1. MIB-1 showed a mildly increased proliferative index, and S100 protein highlighted dermal dendritic cells incorporated within the lesion. Many of the lesional cells were positive for CD68.

DISCUSSION

Epithelioid cell histiocytoma, which is considered a benign entity, has classically been a source of frustration for clinical dermatologists and dermatopathologists alike. Diagnosis is difficult, in part, because of the low incidence of this type of lesion (approximately 1.4% of all histiocytomas¹), the historically disputed cell of origin,² and the lack of consistent staining for any immunohistochemical marker. Clinically, ECH appears pedunculated and hyperpigmented and is usually smaller than 2.0 cm in greatest diameter. The most common site of presentation is the . . . [Full Text of this Article]

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Arch Dermatol. 2008;144(1):105-110.
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