This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Diagnosis  • Dermatologic Disorders, Other  • Alert me on articles by topic

Arch Dermatol. 2008;144(1):105-110.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Langerhans cell histiocytosis (LCH).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histopathologic examination of the punch biopsy specimen showed a dense mononuclear cell infiltrate in the superficial dermis, composed of histiocytes with kidney-shaped nuclei, lymphocytes, and eosinophils. The histiocytes were positive for S100 protein and CD1a. Radiologic imaging studies demonstrated multiple small lytic lesions in the skull and mild degenerative changes in the thoracic and lumbar spine. Magnetic resonance imaging of the brain and pituitary suggested enhancement and nodularity of the infundibulum with mild enhancement of the hypothalamus. A computed tomographic scan of the abdomen did not show any hepatosplenomegaly.

The patient was treated with betamethasone gel, 0.05%, twice a day to lesions on his scalp and clindamycin phosphate gel, 1%, to eroded areas. His skin lesions partially responded to the treatment with no further progression. He received follow-up care by the medical oncology and endocrine services and was treated with desmopressin acetate for diabetes insipidus and testosterone gel for hypogonadism.

DISCUSSION

. . . [Full Text of this Article]

RELATED ARTICLE

Multiple Erythematous Eroded Patches and Papules on the Scalp—Quiz Case
Sanjay Mandal, Steven Q. Wang, Klaus Busam, Mark L. Heaney, and Liang Deng
Arch Dermatol. 2008;144(1):105-110.
EXTRACT | FULL TEXT