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Recurrent Pustular Eruption in an Infant—Diagnosis
Arch Dermatol. 2008;144(1):105-110.
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Diagnosis: Infantile eosinophilic pustular folliculitis (EPF).
MICROSCOPIC AND LABORATORY FINDINGS AND CLINICAL COURSE
Histopathologic examination of a pustular lesion revealed a hair follicle that had been partially destroyed by an intense mixed inflammatory infiltrate. The infiltrate, which was mainly composed of eosinophilic leukocytes, extended to the perifollicular area. The patient had leukocytosis, with prominent peripheral eosinophilia. Total and specific serum IgE levels were within normal limits. Swabs for bacteriologic and mycologic cultures failed to yield any organisms, and scrapings were negative for scabies. The patient was diagnosed as having infantile EPF. After the biopsy, a rapid, spontaneous resolution occurred a few days later, and no recurrence has been noted in 11 months of follow-up.
DISCUSSION
Infantile EPF is a rare, self-limiting disorder of unknown etiology. Since the first case of EPF in infancy was described by Lucky et al1 in 1984, fewer than 50 cases of infantile EPF have been reported. Most cases of EPF are diagnosed in children, and there is a marked . . . [Full Text of this Article]
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Arch Dermatol. 2008;144(1):105-110.
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