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Alon Scope, MD; Cristiane Benvenuto-Andrade, MD; Melissa Gill, MD; Marco Ardigo, MD; Salvador Gonzalez, MD, PhD; Ashfaq A. Marghoob, MD
Memorial Sloan-Kettering Cancer Center, New York, New York (Drs Scope, Benvenuto-Andrade, Gill, Gonzalez, and Marghoob); San Gallicano Dermatological Institute–Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) (Dr Ardigo), Rome, Italy

Arch Dermatol. 2008;144(1):134.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Reflectance confocal microscopy (RCM) allows noninvasive imaging of the skin at cellular-level resolution. However, unlike pathologic analysis, RCM obtains horizontal optical sections (en face). We present RCM images (Figure 1A and Figure 2A) with histopathologic correlation (Figure 1B and Figure 2B) of molluscum contagiosum, a viral infection that manifests clinically as solitary or multiple umbilicated, dome-shaped papules (Figure 1C). The 4 x 4-mm RCM mosaic image (Figure 1A) shows a round, well-circumscribed lesion with central round cystic areas filled with brightly refractile material. The corresponding histopathologic image (Figure 1B [hematoxylin-eosin, original magnification x20]) shows several regular, rounded, squamoid lobules opening into central dilated infundibula filled with keratotic plugs. (The line in Figure 1B indicates . . . [Full Text of this Article]