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What This Observation Tells Us About the Naturally Occurring Disease

David F. Fiorentino, MD, PhD

Arch Dermatol. 2008;144(10):1379-1382.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Adverse events associated with medication use are a bane for physicians. However, when an adverse effect goes beyond an isolated clinical or laboratory finding and is instead a phenocopy of a naturally occurring disease state, we are presented with an opportunity to understand disease pathogenesis. The less common situation in which a disease state is reproduced with a naturally occurring biologic substance (ie, cytokine or hormone) makes even the most jaded of clinicians stand up and take note. The association of supraphysiologic amounts of an endogenous molecule with an induced disease state hardly provides physiologic proof of its connection in the spontaneously occurring disease, but it provides another level of evidence in a world in which the study of human disease rarely affords one with the opportunity to perform an in vivo experiment. It is with this level of interest and caution that we should . . . [Full Text of this Article]

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