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VIGNETTES
Limited Effects of UV-A1 Phototherapy in 3 Patients With Nephrogenic Systemic Fibrosis
Alexander Kreuter, MD;
Thilo Gambichler, MD;
Stefan M. Weiner, MD;
Gisela Schieren, MD
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Nephrogenic systemic fibrosis (NSF) is an emerging sclerodermalike disease that affects almost exclusively patients undergoing hemodialysis for end-stage renal disease (ESRD). Increasing evidence indicates that NSF is induced by gadolinium-based contrast agents commonly used in magnetic resonance imaging (MRI). Nephrogenic systemic fibrosis may result in significant morbidity and mortality, and a high proportion of patients end up in wheelchairs or become bedridden because of their progressive joint contractures. To date, no consistently effective therapy is available for NSF. Phototherapy with UV-A1, frequently used for other sclerotic skin diseases, has been reported to have beneficial effects in NSF.1 We herein report our results from 3 patients treated with UV-A1 phototherapy (Table).
Table appears in full text version.
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Table. Clinical Characteristics and Responses to UV-A1 Phototherapy
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Report of a Case
A 50-year-old man presented with a rapid onset of diffusely thickened hyperpigmented skin affecting all 4 extremities. . . . [Full Text of this Article]
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Arch Dermatol 2009;145:1164-1169.
ABSTRACT
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Estimates of Risk, Empirical Treatment Observations, and Unexpected Laboratory Findings Reveal the Complexity of Nephrogenic Systemic Fibrosis
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Arch Dermatol 2009;145:1178-1182.
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