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Remodeling of the Dermoepidermal Junction in Superficial Spreading MelanomaInsights Gained From Correlation of Dermoscopy, Reflectance Confocal Microscopy, and Histopathologic Analysis
Alon Scope, MD;
Iris Zalaudek, MD;
Gerardo Ferrara, MD;
Giuseppe Argenziano, MD;
Ralph P. Braun, MD;
Ashfaq A. Marghoob, MD
Arch Dermatol. 2008;144(12):1644-1649.
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Diagnosis in dermatology, whether rendered clinically or histopathologically, relies on the analytical examination of the primary morphologic features of the lesion on the gross or microscopic level, respectively. During the past 2 decades, we have begun to appreciate a new dimension in primary morphologic analysis, namely, the in vivo, en face macroscopic and microscopic morphologic features as seen via dermoscopy and reflectance confocal microscopy (RCM). Like dermoscopy, RCM reveals morphologic details of architecture in the en face plane, but, in addition, it provides morphologic information on the cellular level.1 The ability to visualize a lesion's primary morphologic features on multiple different levels has fueled new insights into the biological evolution of lesions. This month's Archives of Dermatology features an important article by Pellacani et al2 that correlates dermoscopic structures of . . . [Full Text of this Article]MODEL OF EARLY MM PROGRESSION
INTERPRETING DERMOSCOPIC AND RCM FINDINGS IN MM
EXPANSION WITHIN UNDULATING DEJ REMODELING OF THE DEJ AND STROMA
DERMAL INVASION
CONCLUSION
AUTHOR INFORMATION
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In Vivo Confocal Microscopic and Histopathologic Correlations of Dermoscopic Features in 202 Melanocytic Lesions
Giovanni Pellacani, Caterina Longo, Josep Malvehy, Susana Puig, Cristina Carrera, Sonia Segura, Sara Bassoli, and Stefania Seidenari
Arch Dermatol. 2008;144(12):1597-1608.
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