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Solitary Nodule on the Thigh—Diagnosis
Arch Dermatol. 2008;144(2):255-260.
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Diagnosis: Cutaneous lymphadenoma.
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Histologic examination of the biopsy specimen revealed multiple islands of basaloid cells within the reticular dermis and subcutaneous fat. The islands were round, oval, or occasionally angular and were surrounded by a fibrotic stroma. No connection to the overlying epidermis was observed. Areas of peripheral palisading were noted as well as some centrally located larger pale epithelial cells, but the most striking feature was the presence of numerous lymphocytes within each island. Stromal-epithelial clefts and atypical mitotic figures were absent. A few ducts were observed in some of the tumor islands.
DISCUSSION
Cutaneous lymphadenoma was originally described by Santa Cruz and Barr1 in 1987 as a lymphoepithelial tumor of the skin, renamed in 1991 to cutaneous lymphadenoma.2 They occur in persons aged 14 to 79 years, but most cases are reported in young to middle-aged adults. Typical lesions are flesh-colored to pink papules or nodules, most commonly localized to . . . [Full Text of this Article]
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Arch Dermatol. 2008;144(2):255-260.
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