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A Fertile Biological Hunting Ground

Laurent Parmentier, MD, PhD; Peter M. Steijlen, MD, PhD; Maurice A. M. van Steensel, MD, PhD

Arch Dermatol. 2008;144(3):384-385.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of the Archives, Kabashima et al¹ describe a Japanese teenager with a hyperhidrotic, erythrodermic, transgredient nonsyndromic palmoplantar keratoderma (PPK). In finding phenotypic similarities with other patients formerly described in the Japanese dermatology literature, Kabashima and colleagues convincingly argue that their patient probably represents the recessive type of keratoderma first described by Nagashima et al² in 1977. Autosomal recessive inheritance was speculated in view of the lack of parental transmission and the occurrence of the disease in multiple affected siblings.

How does Nagashima-type keratosis compare with other autosomal recessive PPKs? It strongly resembles mal de Meleda (MDM) but appears to have less severe skin symptoms and does not have the associated abnormalities that distinguish MDM. Kagashima and coauthors further substantiate their assertions by showing that their patient has no SLURP-1 mutations, . . . [Full Text of this Article]

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"Nagashima-Type" Keratosis as a Novel Entity in the Palmoplantar Keratoderma Category
Kenji Kabashima, Jun-ichi Sakabe, Yoko Yamada, and Yoshiki Tokura
Arch Dermatol. 2008;144(3):375-379.
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