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Solitary Nodule in a 3-Month-Old Male Infant—Diagnosis
Arch Dermatol. 2008;144(3):405-410.
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Diagnosis: Solitary congenital infantile myofibroma/myopericytoma.
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Findings from histologic examination showed whorls and fascicles of smooth muscle, as well as spindle-shaped myofibroblastic cells in a fibrous stroma. Additional round to oval cells were present with surrounding vascular channels, resembling the hemangiopericytoma pattern characteristic of these tumors. A trichrome stain confirmed the presence of smooth muscle, and an actin stain showed strong positivity. Further evaluation of the infant confirmed the solitary nature of the lesion. The patient was referred to the plastic surgery department for conservative excision of the lesion owing to its rapid growth rate.
DISCUSSION
Infantile myofibromatosis was first recognized as a condition of benign fibrous spindle cell tumors in 1954,1 originally termed congenital fibromatosis. It was further classified in 1981 by Chung and Enzinger,2 who recognized its myofibroblastic characteristics. Most recently, infantile myofibroma has been termed myopericytoma because of its clinicopathologic connection to infantile hemangiopericytoma.3 It is thought that these tumors comprise a spectrum . . . [Full Text of this Article]
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