Diagnosis: Plantar fibromatosis (Ledderhose disease).
MICROSCOPIC FINDINGS
Histologic examination revealed intermingled fascicles of spindle-shaped fibroblasts within the reticular dermis. Tumor cells were of uniform size and shape, with ovoid and elongated nuclei. There was no atypia or mitosis. No invasion to the surrounding structures was noted.
DISCUSSION
Plantar fibromatosis (PLF) is a benign and superficial form of fibromatosis, characterized by the replacement of the plantar aponeurosis with abnormal fibrous tissue.1-4 The disorder is accepted as the plantar equivalent of palmar fibromatosis (Dupuytren disease); however, PLF is much more rarely encountered.3, 5-7 It usually affects men in the fourth to seventh decade of life.1, 6 However, the disorder may rarely present in childhood and even at birth.7
The etiology remains unknown. In contrast to Dupuytren disease in which an autosomal dominant inheritance has been firmly established, familial PLF is rare.5 Trauma, infection, neuropathy, biochemical and metabolic imbalance, faulty development, and occupation have been proposed as potential etiological factors.2 We believe that . . . [Full Text of this Article]
