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Bluish Subcutaneous Nodule in a Child—Diagnosis
Arch Dermatol. 2008;144(4):547-552.
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Diagnosis: Fibrous hamartoma of infancy.
MICROSCOPIC FINDINGS
The biopsy findings showed a subcutaneous proliferation with 3 different tissue components: trabeculae of interlacing fibrous tissue, nests or whorls of spindle cells in a mucinous matrix (mesenchymal cells), and mature fat. Fibrous trabeculae, composed of spindle-shaped cells in a densely collagenous stroma, intersected mature fat lobules and nests of immature spindle-shaped to stellate cells in myxoid stroma.
DISCUSSION
Fibrous hamartoma of infancy (FHI) is a rare, benign, mesenchymal tumor that can occur congenitally or appear during early childhood, with 90% of cases arising within the first year of life.1 The tumor is usually slow growing, although it may initially undergo a period of rapid growth.2 Generally, FHI presents as a painless, freely movable, firm, solitary mass, but cases of multiple synchronous lesions have been reported.3 A solitary lesion may also consist of multiple nodules. Typically, FHI lesions range from 0.5 to 4.0 cm in diameter, but lesions as large as . . . [Full Text of this Article]
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Arch Dermatol. 2008;144(4):547-552.
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