This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Pediatrics  • Pediatrics, Other  • Diagnosis  • Dermatologic Disorders, Other  • Alert me on articles by topic

Arch Dermatol. 2008;144(5):673-678.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Symmetrical Borrelia burgdorferi–associated lymphocytoma cutis of the eyebrows.

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histologic examination showed a dense lymphoid infiltrate in the dermis with formation of confluent germinal centers, surrounded by a small mantle zone (Figure 2). Numerous "tingible body" macrophages were present within the germinal centers (Figure 3), which were outlined by CD21-positive follicular dendritic cells. The germinal center cells were positive for CD20, CD10, and Bcl-6 and negative for Bcl-2. The proliferation marker MIB-1 (Ki-67) showed a normal (high) proliferation of germinal center cells. Molecular analysis of the immunoglobulin heavy chain (IGH) gene rearrangement by polymerase chain reaction (PCR) revealed a polyclonal smear. Based on these findings, a diagnosis of lymphocytoma cutis was made. Association with Borrelia burgdorferi infection could be confirmed by PCR analysis from the paraffin material, demonstrating the presence of a specific band at the expected length. Serologic findings from B burgdorferi infection showed positive IgG, but negative IgM, antibodies. The patient . . . [Full Text of this Article]

DISCUSSION

RELATED ARTICLE

Symmetrical Reddish Swelling of the Eyebrows in a 12-Year-Old Girl—Quiz Case
Michael Emberger, Martin Laimer, Christoph M. Lanschuetzer, Silvia Selhofer, and Lorenzo Cerroni
Arch Dermatol. 2008;144(5):673-678.
EXTRACT | FULL TEXT