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Lamotrigine-Induced Toxic Epidermal Necrolysis Treated With Intravenous Immunoglobulin and Amniotic Membranes
Rodrigo Schwartz, MD;
Esteban Avello, MD;
Francis Palisson, MD
Arch Dermatol. 2008;144(6):724-726.
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INTRODUCTION
Toxic epidermal necrolysis is a life-threatening skin disease. Our case is an attempt to improve its outcome using a novel coadjuvant treatment plan.
REPORT OF A CASE
A 36-year-old Chilean woman with depressive disorder was prescribed treatment with lamotrigine starting at a dosage of 25 mg/d and increasing 25 mg per week. When she reached 75 mg/d at the third week, she presented with an acute abdominal skin eruption. She was evaluated in an emergency department and received 1 dose of sodium phosphate betamethasone and dexchlorpheniramine maleate, 5.3 mg, intravenously, which resulted in partial relief of symptoms for a few hours. The following day she presented with fever with a body temperature up to 38.5°C and a generalized erythematous maculopapular skin eruption, along with few bullae on friction-prone areas and erosions on her oral mucosa and lips. In the next hours, the eruption rapidly became . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
AUTHOR INFORMATION
Servicio de Dermatología, Hospital Clínico Universidad de Chile, and Departamento de Dermatologia, Clinica Las Condes (Dr Schwartz), Debra-Chile Foundation (Drs Schwartz, Avello, and Palisson), and Departamento de Dermatología, Facultad de Medicina, Universidad del Desarrollo-Clinica Alemana (Dr Palisson), Santiago, Chile
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