 |
|
VIGNETTES
Scleredema Diabeticorum Case Series: Successful Treatment With UV-A1
Elisabeth B. M. Kroft, MD;
Elke M. G. J. de Jong
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
Scleredema, an uncommon condition with unknown pathophysiologic characteristics, is characterized by nonpitting induration of the skin with occasional erythema. Limited options are available to treat patients with scleredema diabeticorum. We report herein the effect of UV-A1 treatment (340-400 nm) in 3 patients with severe scleredema diabeticorum.
Report of Cases
Two men (patients 1 and 2) and 1 woman (patient 3) (aged 51, 66, and 52 years, respectively) with long-standing, difficult-to-regulate diabetes mellitus presented with a history of tightening of the skin on their backs. Examination revealed nonpitting induration of the back, neck, and shoulders. The mobility of the neck and shoulders was severely limited. No other skin abnormalities or laboratory disorders (eg, paraproteinemia or eosinophilia) were seen. The histologic findings included a thickened broad dermis with mucin between thickened collagen bundles, consistent with scleredema diabeticorum (Figure 1).
Figure appears in full text version.
|
|
|
|
|
Comment
AUTHOR INFORMATION
RELATED ARTICLES
Effect of Increased Pigmentation on the Antifibrotic Response of Human Skin to UV-A1 Phototherapy
Frank Wang, Luis A. Garza, Soyun Cho, Reza Kafi, Craig Hammerberg, Taihao Quan, Ted Hamilton, Maureen Mayes, Voravit Ratanatharathorn, John J. Voorhees, Gary J. Fisher, and Sewon Kang
Arch Dermatol. 2008;144(7):851-858.
ABSTRACT
| FULL TEXT
UV-A1 Phototherapy for Sclerotic Skin Diseases: Implications for Optimizing Patient Selection and Management
Alexander Kreuter and Thilo Gambichler
Arch Dermatol. 2008;144(7):912-916.
EXTRACT
| FULL TEXT
|
