 |
|
COMMENTS AND OPINIONS
Eczematoid Graft-vs-Host Disease—Reply
Daniel Creamer, MD;
Claire Martyn-Simmons, MD;
Anthony Du Vivier, MD
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
In reply
We were interested to read Cook-Norris and Weenig's comments on our description of 10 patients who, after allogeneic hematopoietic stem cell transplantation, developed a chronic eczema that was histopathologically characterized by features of both GVHD and dermatitis. We have described this eruption as an eczematoid form of chronic cutaneous GVHD.1 However, Cook-Norris and Weenig suggest that the clinicopathologic features point away from a chronic GVH reaction and argue that the dermatosis represents a papulosquamous variant of acute GVHD.
In our experience, acute cutaneous GVHD presents and behaves differently from the eruption that Cook-Norris and Weenig described. Acute GVHD is an exanthem of macular, usually morbilliform, erythema with acral and mucosal involvement. In hyperacute GVHD, extensive keratinocyte necrosis may lead to blistering and a toxic epidermal necrolysis–like picture. Most cases of acute GVHD can be controlled rapidly with systemic . . . [Full Text of this Article]
AUTHOR INFORMATION
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
Eczematoid Graft-vs-Host Disease: A Novel Form of Chronic Cutaneous Graft-vs-Host Disease and Its Response to Psoralen–UV-A Therapy
Daniel Creamer, Claire L. Martyn-Simmons, Genevieve Osborne, Michelle Kenyon, Jon R. Salisbury, Stephen Devereux, Antonio Pagliuca, Aloysius Y. Ho, Ghulam J. Mufti, and Anthony W. P. du Vivier
Arch Dermatol. 2007;143(9):1157-1162.
ABSTRACT
| FULL TEXT
RELATED LETTER
Eczematoid Graft-vs-Host Disease
Robert H. Cook-Norris and Roger H. Weenig
Arch Dermatol. 2008;144(8):1066.
EXTRACT
| FULL TEXT
|
