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COMMENTS AND OPINIONS
The Role of Narrowband UV-B Plus Alefacept Combination Therapy in the Treatment of Psoriasis
Heidi Jacobe, MD;
Laura Winterfield, MD;
Flora Kim, BS;
Beverley Huet-Adams, MS;
Rachael Cayce, BS
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In the August 2007 issue of the Archives, Legat et al1 described the accelerated and improved clearance of psoriasis when alefacept is combined with narrowband (NB) UV-B phototherapy. Because all patients in this study were treated with alefacept and with a randomly selected body half exposed to NB UV-B phototherapy, the question remained as to whether the improvement seen was greater than what can be achieved with NB UV-B monotherapy. We present data from 16 patients with chronic plaque psoriasis requiring systemic or phototherapy who were enrolled in an institutional review board approved, randomized, double-blind, placebo-controlled study comparing alefacept with NB UV-B vs NB UV-B alone for the treatment of psoriasis.
Patient demographics and baseline disease characteristics are presented in the Table. All patients were treated with a standard course of NB UV-B . . . [Full Text of this Article]
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RELATED ARTICLE
Narrowband UV-B Phototherapy, Alefacept, and Clearance of Psoriasis
Franz J. Legat, Angelika Hofer, Alexandra Wackernagel, Wolfgang Salmhofer, Franz Quehenberger, Helmut Kerl, and Peter Wolf
Arch Dermatol. 2007;143(8):1016-1022.
ABSTRACT
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RELATED LETTER
The Role of Narrowband UV-B Plus Alefacept Combination Therapy in the Treatment of Psoriasis—Reply
Franz J. Legat, Franz Quehenberger, and Peter Wolf
Arch Dermatol. 2008;144(8):1068-1069.
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