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COMMENTS AND OPINIONS
The Role of Narrowband UV-B Plus Alefacept Combination Therapy in the Treatment of Psoriasis—Reply
Franz J. Legat, MD;
Franz Quehenberger, PhD;
Peter Wolf, MD
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In reply
Our recently published half-body comparison study1 has unambiguously shown that NB UV-B irradiation accelerated and improved the clearance of psoriatic lesions in patients treated with alefacept. The administration of NB UV-B did significantly (P < .001) speed up the initial clearance of psoriatic lesions during the 12-week study period, and, by week 12, a PASI reduction of greater than 75% was found significantly more often on NB UV-B–treated body halves (12 of 14 patients [86%]) than on the nonirradiated body halves (6 of 14 [43%]; P < .03).
One question left unanswered by our study was whether NB UV-B alone is equally effective as NB UV-B plus alefacept. Jacobe et al now present data from a placebo-controlled study aiming to answer this question. They compare a 12-week treatment regimen comprising NB UV-B together with alefacept (intramuscular injections, 15 mg, . . . [Full Text of this Article]
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Arch Dermatol. 2007;143(8):1016-1022.
ABSTRACT
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The Role of Narrowband UV-B Plus Alefacept Combination Therapy in the Treatment of Psoriasis
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Arch Dermatol. 2008;144(8):1067-1068.
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