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VIGNETTES
Therapeutic Effect of Argatroban on Rheumatoid Vasculitis With Antiphosphatidylserine-Prothrombin Complex Antibody
Tamihiro Kawakami, MD, PhD;
Masahide Yamazaki, MD, PhD;
Kanade Kawasaki, MD, PhD;
Masako Mizoguchi, MD, PhD;
Yoshinao Soma, MD, PhD
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Rheumatoid vasculitis (RV) is an inflammatory condition of the small and medium-sized vessels that affects a subset of patients with established rheumatoid arthritis (RA). Detection of antiphospholipid cofactor antibodies including antiphosphatidylserine-prothrombin complex (aPS/PT) antibodies in addition to the classic anticardiolipin antibodies and lupus anticoagulant (LAC) seems to be of considerable clinical importance.1 Argatroban is a synthetic monovalent direct anticoagulant and thrombin inhibitor.2
Report of a Case
A 70-year-old Japanese woman had a 35-year history of RA. Her disease had not responded well to treatment with intramuscular gold, methotrexate, D-penicillamine, azathioprine, or cyclosporine. She presented with a 2-week history of skin lesions with myalgias and arthralgias on her lower extremities. She complained of bilateral ankle numbness and a rapid increase in the intensity of her symptoms.
Examination revealed cutaneous ulcerations and livedo reticularis scattered . . . [Full Text of this Article] Comment
AUTHOR INFORMATION
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