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  Vol. 144 No. 8, August 2008 TABLE OF CONTENTS
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VIGNETTES
Therapeutic Effect of Argatroban on Rheumatoid Vasculitis With Antiphosphatidylserine-Prothrombin Complex Antibody

Tamihiro Kawakami, MD, PhD; Masahide Yamazaki, MD, PhD; Kanade Kawasaki, MD, PhD; Masako Mizoguchi, MD, PhD; Yoshinao Soma, MD, PhD

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Rheumatoid vasculitis (RV) is an inflammatory condition of the small and medium-sized vessels that affects a subset of patients with established rheumatoid arthritis (RA). Detection of antiphospholipid cofactor antibodies including antiphosphatidylserine-prothrombin complex (aPS/PT) antibodies in addition to the classic anticardiolipin antibodies and lupus anticoagulant (LAC) seems to be of considerable clinical importance.1 Argatroban is a synthetic monovalent direct anticoagulant and thrombin inhibitor.2

Report of a Case

A 70-year-old Japanese woman had a 35-year history of RA. Her disease had not responded well to treatment with intramuscular gold, methotrexate, D-penicillamine, azathioprine, or cyclosporine. She presented with a 2-week history of skin lesions with myalgias and arthralgias on her lower extremities. She complained of bilateral ankle numbness and a rapid increase in the intensity of her symptoms.

Examination revealed cutaneous ulcerations and livedo reticularis scattered . . . [Full Text of this Article]


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