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Michael Bigby, MD

Arch Dermatol. 2008;144(9):1197-1199.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Commentary on: Isotretinoin and the risk of depression in patients with acne vulgaris: a case-crossover study
Azoulay L, Blais L, Koren G, LeLorier J, Bérard A
J Clin Psychiatry. 2008;69(4):526-532

Question: In patients with acne vulgaris, does treatment with isotretinoin increase the risk of depression?

Design: A case-crossover study was performed among subjects who received 1 or more isotretinoin prescriptions from 1984 through 2003.

Setting: Data were obtained from the Régie de l’Assurance Maladie du Québec (RAMQ) and Quebec's hospital discharge (Med-Echo) administrative databases.

Patients: Cases were defined as those with a first diagnosis or hospitalization for depression (International Classification of Diseases, Ninth Revision codes 296.2, 298.0, 300.4, 309.0, 309.1, and 311) during the study period (1984-2003) and those who filled a prescription for an antidepressant in the 30 days following their diagnosis or hospitalization. The index date was the calendar date of the diagnosis . . . [Full Text of this Article]

Comment


AUTHOR INFORMATION
Department of Dermatology, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts

RELATED LETTER

Does Isotretinoin Increase the Risk of Depression?—Reply
Laurent Azoulay and Anick Bérard
Arch Dermatol. 2008;144(9):1234-1235.
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