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Estrogen Receptor Expression in Cutaneous Melanoma
Marcia S. Driscoll, MD, PharmD;
Jane M. Grant-Kels, MD
Arch Dermatol. 2009;145(1):73-75.
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There has always been some suspicion that a relationship exists between hormones and melanoma. First, case reports in the 1950s suggested an extremely poor prognosis for women diagnosed with melanoma during pregnancy.1-2 It was observed that melanoma rarely occurs prior to puberty,3-4 and women diagnosed with melanoma have higher survival rates than men.5-6 Estrogen receptors (ERs) and progesterone receptors were found in some melanomas.7-8 Greater tumor thickness was reported in melanomas diagnosed in pregnant women compared with nonpregnant controls.9-10
However, our recent review of the literature concerning hormones, nevi, and melanoma11 did not support a clear relationship between endogenous hormones (pregnancy) or exogenous hormones (oral contraceptives or hormonal replacement therapy) and melanoma. We summarized recent case-control studies, which observed no effect of pregnancy on the prognosis of localized (American Joint Committee on Cancer stage I or II) melanoma. We cited strong . . . [Full Text of this Article] DECREASED ERβ EXPRESSION: CORRELATION WITH CARCINOGENESIS?
ERβ EXPRESSION IN MELANOMA AND THE MICROENVIRONMENT OF MELANOCYTES
CLINICAL IMPLICATIONS FOR ERβ EXPRESSION IN MELANOMAS
AUTHOR INFORMATION
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