• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in this journal  Topic Collections  • Dermatology  • Dermatologic Disorders  • Renal Diseases  • Renal Diseases, Other  • Dermatologic Disorders, Other  • Dermatologic Procedures  • Phototherapy  • Drug Therapy  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

Whitney A. High, MDMEng

Arch Dermatol. 2009;145(10):1178-1182.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Nephrogenic systemic fibrosis (NSF) is an acquired condition that occurs in the setting of chronic kidney disease (CKD), and it eventuates as fibrosis of the skin, soft tissues, and sometimes the viscera. For nearly a decade, the cause of NSF remained largely elusive. Only recently have the combined efforts of multiple investigators shed light on key associations and possible reasons for the development of disease. First described by Cowper et al¹ in 2000 (using tissue dating from 1997), NSF was distinguished clinically by thickening and hardening of the skin and histologically by increased dermal spindle cells, with resultant fibrosis and mucin deposition. While in some ways NSF resembles scleromyxoedema, patients lack the characteristic paraproteinemia and other stigmata of that disease.

Since the initial description of NSF, the elucidation of causative factors and associations largely languished. A search of the indexed medical literature from 2000 through 2005, . . . [Full Text of this Article]

INVOLVEMENT OF GADOLINIUM


TREATMENT OPTIONS REFLECT ON A POORLY UNDERSTOOD MECHANISM

CONCLUSIONS

AUTHOR INFORMATION


CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

Large Sample of Nephrogenic Systemic Fibrosis Cases From a Single Institution
Christine U. Lee, Christina M. Wood, Gina K. Hesley, Nelson Leung, Mellena D. Bridges, Jeffrey T. Lund, Peter U. Lee, and Mark R. Pittelkow
Arch Dermatol. 2009;145(10):1095-1102.
ABSTRACT | FULL TEXT  

Detection of Clonal T Cells in the Circulation of Patients With Nephrogenic Systemic Fibrosis
Alexander Kreuter, Stefan Höxtermann, Thilo Gambichler, Christian Tigges, Stephan A. Hahn, and Gisela Schieren
Arch Dermatol. 2009;145(10):1164-1169.
ABSTRACT | FULL TEXT  

UV-A1 Therapy for Nephrogenic Systemic Fibrosis
Kien T. Tran, Heidi B. Prather, Clay J. Cockerell, and Heidi Jacobe
Arch Dermatol. 2009;145(10):1170-1174.
ABSTRACT | FULL TEXT