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Asymptomatic Red Plaque on the Leg of a 7-Year-Old Girl—Diagnosis
Arch Dermatol. 2009;145(10):1183-1188.
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Diagnosis: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) with marked plasmacytic differentiation.
MICROSCOPIC FINDINGS
Hematoxylin-eosin staining of the biopsy specimens showed a diffuse, dense infiltrate in the upper dermis and a patchy, perivascular and periadnexal infiltrate in the lower dermis (Figure 2) composed of predominantly plasmacytoid cells (Figure 3). In situ hybridization revealed a  light-chain–restricted population. Immunohistochemical stains were diffusely positive for CD79a and IgG and essentially negative for CD20, IgD, IgM, and IgA. A fluorescence polymerase chain reaction assay was positive for a clonal immunoglobulin heavy-chain gene rearrangement. Cultures of punch biopsy specimens were negative for bacteria, fungi, and mycobacteria.
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DISCUSSION
Primary cutaneous marginal zone B-cell lymphoma is one of the major types of primary cutaneous B-cell lymphoma in the revised World Health Organization–European Organization for Research and Treatment of Cancer classification.1 It is one of the extranodal marginal zone B-cell lymphomas that most commonly involve mucosal sites, referred to as MALT (mucosa-associated lymphoid tissue) lymphomas, . . . [Full Text of this Article]
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Arch Dermatol. 2009;145(10):1183-1188.
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