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Leflunomide in the Treatment of Palmoplantar Pustulosis
Priti Mohan Melwani, MD;
Yeray Peñate, MD;
Noemi Guillermo, MD;
Elena Soler, MD;
Buenaventura Hernández-Machín, MD;
Leopoldo Borrego, MD
Arch Dermatol. 2009;145(11):1224-1226.
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INTRODUCTION
Palmoplantar pustulosis (PPP) is a chronic inflammatory disease characterized by recurrent pustules on the palms and soles. Its etiology is unknown, and its relationship to psoriasis is not clear. Treatment of PPP can be challenging. Several immunomodulatory drugs have been used with moderate results. Herein, we report 2 cases of PPP that achieved complete remission with leflunomide.
REPORT OF A CASE
CASE 1
In 1995, a 30-year-old woman presented with a 6-day history of fever and pruritic pustules on her left hand. Physical examination revealed confluent pustules surrounded by erythema on the dorsal aspect of the left hand, palm, and wrist (Figure 1). There were no lesions in other locations. Her medical history was otherwise unremarkable.
Figure appears in full text version.
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Figure 1. Patient 1 prior to treatment. The dorsum of the hand has multiple confluent pustules surrounded by erythema . . . [Full Text of this Article]
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CASE 2
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
AUTHOR INFORMATION
Department of Dermatology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain
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