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A Rapidly Growing Lesion on the Lip—Diagnosis
Arch Dermatol. 2009;145(11):1325-1330.
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Diagnosis: Paracoccidioidomycosis (PCM).
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Findings from the lesional biopsy specimen revealed numerous inflammatory granulomas composed of histiocytes and giant cells containing yeastlike formations with multiple gemmulation—diagnostic of PCM—best seen with Grocot stain (Figure 4). Mycological examination confirmed the diagnosis with identification of the Paracoccidioides brasiliensis. Treatment with sulfamethoxazole and trimethoprim was started. Notable reduction of the lesion was obtained within 2 months of specific treatment, and the treatment is to continue for at least 2 years.
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DISCUSSION
Paracoccidioidomycosis is a systemic mycosis caused by the dimorphic fungus P brasiliensis. The disease is endemic to Latin America, and Brazil is responsible for 80% of all reported cases.1 Initially the cases diagnosed in the Amazon rain forest were, usually, in persons from other regions. With identification of the infection in the native indigenous population and occurrence of the disease in children, the Amazon rain forest region can now be considered an emerging endemic . . . [Full Text of this Article]
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Arch Dermatol. 2009;145(11):1325-1330.
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