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Extracorporeal Photochemotherapy for Generalized Deep Morphea
Jason H. Neustadter, MD;
Frank Samarin, MD;
Kacie R. Carlson, PA-C;
Michael Girardi, MD
Arch Dermatol. 2009;145(2):127-130.
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INTRODUCTION
Morphea, or localized scleroderma, can at times constitute a severely disabling and aggressive disease with no single therapy proven to be curative or the standard of care. Herein, we report the case of a patient with severe disabling generalized deep morphea who showed a marked clinical response to treatment with extracorporeal photochemotherapy (ECP).
REPORT OF CASE
Ten years ago, a 49-year-old white patient presented with a reticulated erythema and induration of her abdominal skin. Over the next 5 years, the erythema and induration progressed to include the skin over her lower extremities, chest, back, and upper extremities. With the onset of new lesions, she frequently experienced pruritus and tenderness at the areas of involvement. She also noted decreased ranges of motion in her shoulders. After a 2-year period without progression, she again developed worsening of her symptoms with progression . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
AUTHOR INFORMATION
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
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