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Putting the Risk Into Context

Robert Sidbury, MD, MPH

Arch Dermatol. 2009;145(3):319-320.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Hemangiomas of infancy (IH) are the most common benign tumor of childhood.¹ When small and located in nonvital areas, IH may be safely observed; however, approximately 10% to 20% become "problematic" and require intervention (Figure).² The gold standard therapy is systemic glucocorticoids (GCs).³ Glucocorticoids have the following well-recognized adverse effects in infants⁴: irritability, gastrointestinal tract upset, appetite change, decreased growth while receiving treatment, fungal skin infection, hirsutism, cushingoid facies, hypertension, pneumocystis pneumonia, and hypothalamic-pituitary-adrenal (HPA) axis suppression, a potentially devastating adverse effect, which in the appropriate clinical setting may lead to adrenal crisis.

Figure appears in full text version. Figure. Complications of infantile hemangiomas. *Typically in the setting of large liver hemangiomas and/or multiple cutaneous hemangiomas. Kasabach-Merritt phenomenon, typically in the setting of proliferative vascular tumors of infancy other than infantile hemangiomas (eg, kaposiform hemangioendothelioma). Typically in the setting of a subglottic hemangioma often with cutaneous involvement in a . . . [Full Text of this Article]

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