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Multiple Violaceous Nodules in a Neonate—Diagnosis
Arch Dermatol. 2009;145(3):321-326.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Diagnosis: Congenital leukemia cutis.
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Histopathologic examination revealed diffuse dermal and subcutaneous infiltration by monomorphic cells with a thin rim of eosinophilic cytoplasm, large hyperchromatic nuclei, and high mitotic activity. Histopathologic staining was positive for leukocyte common antigen in these cells. The peripheral blood smear showed that 34% of the myeloid series of cells were monoblasts, bone marrow aspirate results showed 71% blast cells, and a biopsy specimen confirmed the diagnosis of congenital acute myeloid leukemia, with flow cytometry findings positive for M4 and M5 phenotype. Cytogenetic analysis of peripheral blood by G-banding revealed a normal karyotype. Complete remission was attained with multidrug chemotherapy, with no recurrence at the 1-year follow-up examination.
DISCUSSION
Congenital leukemia is an extremely rare disease with an estimated incidence of 1 per 5 million live births.1 It has been frequently reported with Down syndrome, Turner syndrome, and Klinefelter syndrome, but our patient had none of these. Maternal exposure to radiation, high . . . [Full Text of this Article]
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Arch Dermatol. 2009;145(3):321-326.
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