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Healing Aided by Naltrexone

Albert Stuart Reece, MBBS(Hons), FRCS(Ed), FRCS(Glas), FRACGP, MD

Arch Dermatol. 2009;145(4):375-377.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Obesity, insulin-dependent diabetes mellitus, a sedentary lifestyle, and chronic ulceration can all be complicated by refractory substance abuse. A case is presented featuring significant improvement of these parameters and others, including successful resolution of the refractory ulceration after control with naltrexone hydrochloride implants. The case is important both as a novel form of treatment for ulcer healing in drug-dependent persons, and for potential pathophysiological insights to wound healing that might be suggested by the likely mechanisms of action of naltrexone.

REPORT OF A CASE

A 54-year-old man, 174 cm tall and weighing 117 kg (body mass index, calculated as weight in kilograms divided by height in meters squared, 38.6), with poorly controlled insulin-dependent diabetes mellitus and a long history of severe polydrug abuse (including benzodiazepines, cannabis, and heroin, 1-3 g/d for a total of 33 years, currently prescribed methadone hydrochloride, 70 mg/d) presented with a 10-month . . . [Full Text of this Article]

THERAPEUTIC CHALLENGE

SOLUTION

COMMENT

AUTHOR INFORMATION

Southcity Family Medical Centre and University of Queensland Medical School, Highgate Hill, Queensland, Australia

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