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Genetics Meets Immunology

Rajan P. Nair, PhD; Jun Ding, MS; Kristina Callis Duffin, MD; Cynthia Helms; John J. Voorhees, MD; Gerald G. Krueger, MD; Anne M. Bowcock, PhD; Goncalo R. Abeçasis, PhD; James T. Elder, MD, PhD

Arch Dermatol. 2009;145(4):462-464.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

More than 25 years of accumulating evidence strongly implicates the immune system in the pathogenesis of psoriasis, including both acquired immunity (T cells) and innate host defense (macrophages, antigen-presenting cells, and keratinocytes). Psoriasis also has a strong genetic component, but the identity of the genes involved has largely remained obscure. In a study recently published in Nature Genetics,¹ these 2 themes of psoriasis—genetics and immunology—come together in a coherent and clinically relevant way.

The genetic makeup of psoriasis is multifactorial: multiple genes and the environment conspire to increase one's risk of developing psoriasis. Like several other multifactorial autoimmune disorders, psoriasis manifests strong HLA associations. In 2006, HLA-Cw6 was found to be the likely cause of . . . [Full Text of this Article]

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