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Molly Hinshaw, MD

Arch Dermatol. 2009;145(4):475-477.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Distribution and Significance of Occult Intraepidermal Tumor Cells Surrounding Primary Melanoma
NorthJP, Kageshita T, Pinkel D, LeBoit PE, Bastian BC
J Invest Dermatol. 2008;128(8):2024-2030

Primary melanoma can recur at the excision site if not excised with a safety margin of surrounding uninvolved skin. To characterize the nature of residual melanoma in the skin surrounding primary tumors targeted by safety margins, we used array comparative genomic hybridization and fluorescent in situ hybridization to detect and spatially map aberrations in the skin adjacent to acral melanomas. Melanocytic cells with genetic amplifications in histopathologically normal skin (field cells) were detected exclusively in the epidermis in 84% of 19 cases, with a mean extension of 6.1 mm (in situ melanomas) and 4.5 mm (invasive melanomas) beyond the histopathological margin. Genetic profiling of these field cells indicated that they represent an early phase of disease preceding melanoma in situ. The extent . . . [Full Text of this Article]

COMMENT

AUTHOR INFORMATION

Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison

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