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John J. Zone, MD

Arch Dermatol. 2009;145(5):585-587.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The goal of clinical research is to answer questions that affect the way in which we care for our patients. This process involves studying data from large numbers of patients with a particular disease and then applying the conclusions to an individual patient. The path of this deductive journey is fraught with many land mines. We must identify these obstacles and continue forward to make the conclusions as applicable as possible to our patient. The work by Abasq et al¹ from Rouen University Hospital in France has assessed the predictive values of anti–desmoglein 1 and 3 (Dsg1 and Dsg3) antibody enzyme-linked immunosorbent assay (ELISA) values for the occurrence of relapses in the management of pemphigus. This work has provided significant answers that help the practitioner in treating a patient with pemphigus. Predictably, it has created new questions. In this editorial, I review the basic questions that . . . [Full Text of this Article]

WHAT ARE THE CLINICAL, HISTOLOGICAL, AND IMMUNOPATHOLOGICAL CHARACTERISTICS OF PEMPHIGUS?


ARE ANTIBODIES THAT BIND TO THE CELL SURFACE OF KERATINOCYTES PATHOGENIC?

ARE ANTIBODIES TO Dsg1 AND Dsg3 PATHOGENIC?

ARE THERE OTHER ANTIBODIES THAT COULD BE PATHOGENIC IN PEMPHIGUS AND NOT BE MEASURED IN THE CURRENT Dsg1 AND Dsg3 ASSAYS?

WHAT IS THE UTILITY OF THE CURRENT ELISA ASSAY FOR Dsg1 AND Dsg3?

IS THE CURRENT ELISA ASSAY USEFUL IN MANAGING PEMPHIGUS IN AN INDIVIDUAL PATIENT?

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ELISA Testing of Anti–Desmoglein 1 and 3 Antibodies in the Management of Pemphigus
Claire Abasq, Hugo Mouquet, Danièle Gilbert, François Tron, Vanessa Grassi, Philippe Musette, and Pascal Joly
Arch Dermatol. 2009;145(5):529-535.
ABSTRACT | FULL TEXT