This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Oncology  • Skin Cancer  • Oncology, Other  • Dermatology  • Dermatologic Disorders  • Neoplasms  • Diagnosis  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Dermatol. 2009;145(5):589-594.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diagnosis: Epithelioid sarcoma (ES) (metastatic).

MICROSCOPIC FINDINGS AND CLINICAL COURSE

Histologic examination revealed a dermal nodular biphasic proliferation composed of pleomorphic epithelioid cells with irregular hyperchromatic nuclei, prominent nucleoli, abundant eosinophilic cytoplasm, and plump spindle cells. The cells dissected between the collagen bundles and focally formed a pseudogranulomatous pattern around relatively acellular zones of degenerated connective tissue (Figure 3). Mitotic figures were occasionally noted (Figure 4). Immunohistochemical analysis revealed the proliferation to be positive for vimentin, pancytokeratin, and smooth muscle actin and negative for S100, HMB45, and CD31 stains. In addition, the epithelioid component exhibited strong reactivity with epithelial membrane antigen. These findings are characteristic of ES.

Figure appears in full text version. Figure 3.

Figure appears in full text version. Figure 4.

DISCUSSION

First described by Enzinger¹ in 1970, ES is a rare aggressive sarcoma of uncertain origin.^1-3 It most commonly presents as a painless slow-growing dermal or subcutaneous nodule with occasional ulceration over the hands and digits of young adult males. Other less commonly affected sites include . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Giant Fleshy Mass Over the Left Axilla—Quiz Case
Ossama Abbas, Samer Ghosn, Adele Chedraoui, and Abdul Ghani Kibbi
Arch Dermatol. 2009;145(5):589-594.
EXTRACT | FULL TEXT