 |
|
Papules on the Nape—Diagnosis
Arch Dermatol. 2009;145(5):589-594.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
Diagnosis: Postherpetic granuloma annulare–like reaction (Wolf isotopic response).
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Histopathologically, the lesion showed an almost normal epidermis and a granulomatous inflammation composed of epithelioid cells, multinucleated giant cells, and lymphocytes in the superficial and middle dermis. Alcian blue staining revealed mucin deposition in the granulomas. There was some degeneration of collagen fibers. Perineural inflammatory infiltrates and thrombosis were observed in the deep dermis and subcutaneous tissue. At 1 week after biopsy, the lesions had almost disappeared without any treatment.
DISCUSSION
A cutaneous reaction at an already healed site of an unrelated disease is known as the Wolf isotopic response.1 The preceding disease is usually a herpesvirus infection, commonly varicella zoster virus infection as well. The most common type of isotopic response is a granuloma annulare–like reaction, but other manifestations, including malignancies (eg, breast carcinoma, skin cancer, and leukemia), immune disorders (eg, lichen planus), and infections (eg, dermatophytosis and verucca), have been reported.2 The interval between the first and second outbreaks . . . [Full Text of this Article]
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
Papules on the Nape—Quiz Case
Tessin Watanabe, Yuichi Yoshida, and Osamu Yamamoto
Arch Dermatol. 2009;145(5):589-594.
EXTRACT
| FULL TEXT
|
