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What Can We Learn From Location?

Florent Grange, MD, PhD; Frank Antonicelli, PhD

Arch Dermatol. 2009;145(6):710-712.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of the Archives, 2 American working groups describe 2 distinct subsets of cutaneous T-cell lymphomas (CTCLs) with a limb location and poor prognosis.^1-2 Poligone et al¹ report 3 cases of unusual variants of CTCL that originated on the lower legs of elderly patients (median age, 82 years) and had an aggressive behavior, with rapid relapses after radiotherapy and resistance to other treatments. Woo et al² studied prognostic factors in a series of 48 patients with primary cutaneous anaplastic T-cell lymphoma (PCATCL) and identified a small subset of 4 cases with an extensive limb disease and a more aggressive clinical course. These 4 patients (median age, 73 years) were 25 years older than those with the classic form of the disease. Three of them had lesions located on the lower limbs. Microarray data revealed that patients with an extensive limb . . . [Full Text of this Article]

ARE LEG VARIANTS OF CUTANEOUS LYMPHOMAS CLINICALLY RELEVANT?


ARE SOME SPECIFIC BIOLOGICAL MECHANISMS INVOLVED IN LEG VARIANTS OF CUTANEOUS LYMPHOMAS?

AUTHOR INFORMATION


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